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KMID : 1143420200130080420
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Public Health Weekly Report
2020 Volume.13 No. 8 p.420 ~ p.429
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Current development status of aptamer diagnosis assay for infectious disease
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Shin Eui-Su
Kim Ki-Seok
Jeon Jun-Ho
Kang Byung-Hak
Rhie Gi-Eun
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Abstract
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Infectious diseases pose a serious threat to public health worldwide. Population growth, urbanization, and pathogenic mutations are known to affect the spread of infectious diseases. Therefore, to minimize and prevent the spread of infectious diseases, rapid and accurate laboratory testing and diagnoses are critical. Aptamers are single-stranded oligonucleotides (ssDNA or RNA) that have similar characteristics to antibodies and that specifically bind to target molecules such as proteins, whole cells, small molecules, viruses, and metal ions, etc. Aptamers are screened through a process known as SELEX (Systematic Evolution of Ligands by EXponential enrichment) in which binding target molecules are selected from a library that has a diversity of about 1014 to 1015 of unique nucleic acid molecules. In the last three decades since aptamers were first introduced in 1990, aptamers and SELEX technology have attracted considerable attention in areas such as cancer treatment and infectious disease diagnosis. In this report, we introduced the diagnostic trends of infectious disease that are based on aptamers.
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KEYWORD
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infectious disease, aptamer, systematic evolution of ligands by exponential enrichment (SELEX), diagnosis
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